Apheresis is used to treat conditions such as glomerulonephritis, thrombotic microangiopathies, and transplant rejection. Nephrology nurses play a key role in patient assessment, vascular access management, monitoring during procedures, and providing education and support. Understanding the different apheresis techniques, indications, equipment, and safety protocols is essential for delivering safe, effective care. Collaboration with the multidisciplinary team ensures optimal outcomes and enhances patient safety.