Obesity is a significant contributor to the progression of conditions such as diabetes, cardiovascular disease, sleep apnea, and fatty liver disease. This session highlights comprehensive, evidence-based approaches to weight management that support improved health outcomes in aging populations. Participants will explore emerging and highly effective pharmacologic therapies, including GLP-1 receptor agonists. The presentation reviews mechanisms of action, appropriate patient selection, monitoring guidelines, and potential adverse effects. Emphasis is also placed on preventing and managing sarcopenia during weight reduction. Attendees will gain practical, clinically relevant strategies to enhance patient care and optimize long-term outcomes.