As health care moves deeper into the new frontier of artificial intelligence, connected devices, virtual care, cloud platforms, and data-driven decision-making, nurse informaticists are uniquely positioned to help protect patients, nurses, and digital health systems. This engaging session invites participants to “think like a hacker” while leading like a nurse: anticipating vulnerabilities, recognizing workflow risks, strengthening human-centered safeguards, and building collaborative defenses across clinical, technical, operational, and executive teams.